‘His urine goes on tour around Europe, showing the kings and queens this glowing pee’: The weird world of alchemy before chemistry

Long before chemistry was a formal science, humans were experimenting with substances to solve problems, cure illnesses and make money. In his book “The Age of Alchemy: How Early Innovators Shaped Modern Chemistry” (Profile Books, 2026), author Kit Chapman, a science journalist and honorary researcher at Falmouth University in the U.K., traces how this ancient, protoscientific tradition shaped the world.

From our ancestors’ early use of fire to some accidental — and disastrous — pyrotechnics in the 14th-century French court of Charles VI, Chapman reveals how early innovations across the world paved the way for modern science.

Live Science spoke with Chapman about his book, which has been short-listed for the 2026 Royal Society Trivedi Science Book Prize.

Hannah Osborne: The book is full of brilliant historical anecdotes that bring all of these alchemy breakthroughs into context. What was your favorite one and why?

Kit Chapman: I mean, you can’t go wrong with a man trying to turn his own urine into gold, I think. Hennig Brand [who accidentally discovered phosphorus in the 17th century] was one of my early touchstones. I’ve known about this story for a while. I’ve always thought, “How can I get this into a book? What’s the link?” Obviously alchemy provides this fantastic base. He bankrupted two wives to try and fund his 1,500-gallon [5,700 liters] urine habit — and then he gets something [phosphorous], against the odds.

This is the first element we can actually put a name to. This is the first person we can say actually discovered a chemical element, and it’s an alchemist in the purest sense of the word. Then, of course, he tries to keep it secret. He sells it, eventually, to a friend, and his urine goes on tour around Europe, showing the kings and queens this glowing pee, before suddenly, [chemist and philosopher] Robert Boyle actually works out exactly what’s going on.

That, to me, sort of encompassed everything I was hoping for in the book. There’s a fantastic story there that’s about human connection. There’s the unraveling of mythology, and theology and belief, and starting to look at science. But there’s also real practical stuff going on there. He didn’t know what he was doing. He just didn’t know why he was doing it, and that I found fascinating.

HO: You make the point that these people weren’t thinking, “Oh, I’m going to do chemistry.” How important is that for understanding how these early innovations shaped modern knowledge of how things work?

KC: I think that’s essential. We often look at science as something separate from the real world, and one of the things that I really wanted to do with this book was to illustrate that science is going on in every profession. It’s going on in every home, continuously; it’s going on in our bodies continuously. It’s everywhere.

Science is a way to understand what’s going on in the world. It is not a separate thing from culture, from belief, from trade, from globalization, from discovery, from just getting on with life. I wanted to bring in the potters, the weavers, the bakers, the urine salesmen — which was an entire thing that I didn’t really know I had to go down. I found it fascinating.

And, of course, [there are] artisans. When we start looking at the first actual chemistry that’s being done, it is people trying to create beautiful works of art, perfumes, things like that. It moves away from survival and into this ecstatic beauty, and that, to me, encompasses what I love about the history of science. It’s bringing all of these threads together and making discoveries not necessarily where we think we’re going to find them.

HO: You mentioned the beauty of it all, and the perfume. One of the chapters I really enjoyed was the first chemist who was a female perfume maker in ancient Assyria.

KC: Tappūtī Bēlet-ekallim. The fascinating thing is that the only reason we know her name is that she put it down in cuneiform. She wrote it down. She may well have been a slave; perfume makers were often slaves. She was certainly a woman who was working in the palace. She was working with another woman whose name, unfortunately, we’ve lost to time.

What I find fascinating is that we now have this person who was one of the working class, one of the underdogs, slaving for a week to make this potion that she wrote down because the recipe is incredibly detailed. And we remember her name, but we have no recollection of the lord or lady that she was actually making it for. It’s kind of class warfare throughout the centuries.

HO: I found the extreme sort of secrecy really striking — that so many of these ancient texts were lost because they were being hidden. But then you also have the fall of civilizations, so we’ve lost all this knowledge.

KC: It’s this combination of, as you mentioned, hiding the recipes because they are trade secrets. If you look at the first alchemy book that we actually know of — “Physika Kai Mystika” — it literally translates as “natural and secret questions” or trade secrets. These were craftsmen, and, of course, they didn’t want to share it with rival craftsmen. If you’ve got a really good recipe for making something look like gold, you want to keep that to yourself.

They use these code words — and that went all the way through into what we think of as alchemy, that sort of Renaissance period where they’re talking about taking the fiery sword from the belly of the dragon, which is just wonderful and descriptive.

But you also have things like Emperor Diocletian destroying the texts in Alexandria in 300 A.D. Why did he do it? Because it was a matter of survival for him. Twenty-five of his predecessors were murdered by their own guards or died of plague and things like that ‪—‬ horrible fates. He wanted to avoid that, and the idea that [someone] could turn something into gold terrified him. It would debase his currency, so it always brings in that politics. It brings in human nature and human curiosity.

HO: Do you think there are still things we’re yet to discover from alchemy from the past?

KC: Yeah, without question. Whether or not we’re going to discover some kind of new, groundbreaking technology that’s going to change the world, I can’t see that happening. But the one thing we could see is the use of natural products in a way that we hadn’t necessarily thought [of].

A great example of that is [Nobel Prize-winning chemist] Tu Youyou and the discovery of artemisinin compounds [from the] qinghao [plant], which comes from a Chinese alchemist’s herbal remedies book, essentially 1,700 years ago. The fact that the best defense we have against malaria, the best antimalarials possible, comes from this ancient alchemical source indicates that there’s probably more to find.

There is almost certainly more to find in terms of how they [ancient alchemists] used recipes, how they would try and make gold. Their understanding of the world is something that we don’t necessarily have a full grasp of, and we’re still piecing it together. There’s some wonderful work being done by Matteo Martinelli and others looking at the history of, particularly of Western alchemy emerging in Egypt.

We also have things like Greek fire. We have a pretty good idea how they did it, but if you’re looking for what the exact recipe [is], we’re still not 100% sure.

HO: It’s interesting now, watching modern equivalents taking place. We still, to an extent, try to guard our own knowledge.

KC: Yeah, we do, and I think it’s actually a pernicious thing in science. We have this publish-or -perish mentality, which is that if we don’t get the paper out first, obviously we lose the patent, but wider than that, we lose the kudos. There’s this kind of necessity to kind of hide things. You hear about all kinds of shenanigans ‪—‬ a reviewer delaying a paper until their paper comes out, things like that, all this kind of naughtiness going on.

We’ve got to recognize that science has moved on certainly from the “Great Man” idea. We’re now working collaboratively in teams. That is the only way that modern science gets done. The second, if there is one lesson from the book, it’s that if you try and hide science, you delay progress.

The moment you actually start spreading ideas, the real ignition for me for the Renaissance and for what becomes chemistry, is the printing press. It’s the fact that ideas can then be shared and accessed by everybody. The moment we start realizing that science is a global endeavor, that everyone can do it ‪—‬ man, woman, child, it doesn’t matter your nationality, [it] doesn’t matter your ethnic ethnicity, it’s for everybody ‪—‬ the sooner we’re going to start seeing some major progress that we otherwise wouldn’t make.

HO: We see loads of the advances in chemistry and alchemy within civilizational melting pots. What were some of the biggest surprises to you when you were researching the book?

KC: One thing that really annoyed me was, looking through textbooks, you can look at who made zinc, and you come up with a name that came from the 1700s, or how platinum was discovered — that’s a fantastic example. Platinum was discovered by a conquistador who noticed that some natives were wearing platinum. But, of course, he didn’t discover it; it was discovered by the Indigenous populations.

The amount of science that came out of Mesoamerica, Central America, and the way that science was also being developed in India, it’s just kind of completely overlooked. If you look at the traditional story of science, we talk about Europe. Occasionally, we might bring in China. But India, Africa, Mesoamerica, South America, North America ‪—‬ every single continent was having scientific discoveries and developments.

They weren’t necessarily developments that we think of in terms of leading to chemistry, but they were dealing with social problems that they had at the time. They were tackling what was in front of them, and we always need to remember when we’re looking at history to look at the context of the discoveries.

HO: Which breakthrough did you think was most impressive in terms of the materials or facilities that were available?

KC: One thing that I found sort of striking was, there’s a chap called Paracelsus who is absolutely fascinating, absolutely bonkers. Paracelsus is, for me, the archetypical alchemist because he was certainly trying to revitalize medicine and get rid of humor theory and come up with all these ideas. [Editor’s note: Humor theory is the idea that human health and temperament were related to four fluids in the body — black and yellow bile, blood and phlegm.] But he also believed that mermaids were real and that they were just out to steal men’s souls.

He was a drunk, he had a broadsword, and yet he’s the guy that was able to combine what we think of as the traditional herbalist role and the doctors. At that point, doctors weren’t even touching patients. They believed that the true skill of a medical man was that you didn’t even need to examine a patient; you could just sort of look at them and you’d know what was wrong. He [Paracelsus] was able to say, “No, that’s not right; you need to actually test things, and you need to try things.” The moment we actually combine those two different threads together is when we actually started to get what becomes of modern medicine. The number of lives that saves is incalculable, so I think that that’s one of the great moments.

The other one that always comes to me is Antoine Lavoisier in the French Revolution. He made several great discoveries — the fact that matter can only be changed; it can’t be destroyed [at least at low energies]. The idea that if you take something, then obviously there’s got to be components to that; you’re not making it out of thin air. And coming up with a list of elements in the French Revolution or just before the French Revolution, unfortunately dies, from the guillotine [when Lavoisier was executed].

That, for me, was when we started to get true chemistry. That’s when all of the magic is dispelled. I think he [Lavoisier] is, for me, the French equivalent of Isaac Newton. He’s incredible.

HO: For you personally, throughout researching and writing the book, what was your biggest takeaway and what was the biggest surprise?

KC: My biggest takeaway is that science happens everywhere continuously through everyone. I traveled around the world for this book; I went to pretty much all of the continents. I didn’t go down to Australia; that’s about it. Wherever you go, there are discoveries being made. There are people who are trying to make their worlds better.

Science is not for this elite group; it’s for everyone. One of the things I try to do with this book is to show people that even if you think that science isn’t for you, it absolutely is; you’re doing science continuously.

There’ve been so many [surprises]. One of the things — this is purely because of the way that I was taught and these inherent biases that we have — but it’s so easy to overlook the role of women. When you start delving into the role of women in science … You’ve mentioned Tappūtī; we also have Mary the Jewess. Throughout the Renaissance, we have people like Caterina Sforza and [the] very famous Queen Christina of Sweden, which I didn’t mention in the book because I just didn’t have space.

The one shocker for me is this book “The Secrets of Isabella Cortese,” which was a man pretending to be a woman to sell his science book. For me, [it] just kind of unravels this whole idea that science isn’t for everyone.